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HESI’s Risk Assessment in the 21st Century (RISK21) Framework: Overview and Applications

Michelle R. Embry, Ph.D, Associate Director Environmental Science, Health and Environmental Science Institute

The HESI Risk Assessment in the 21st Century (RISK21 project developed an integrated risk assessment framework to enhance efficiency and risk management. This framework is an problem formulation-based, exposure driven, tiered data acquisition approach that allows an informed decision on safety to be made when sufficient evidence is available and is risk-based at every step. This approach maximizes the ability to inform decisions and optimize resource usage, and the program also developed a web-based tool that allows users to easily communicate risk-based decisions, whether for a screening and prioritization purpose or a definitive risk assessment. This tool is freely available at This webinar will provide an overview of the RISK21 framework and discuss several case study applications.

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