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HPLC-Triple quadrupole Mass Spectrometry initial developments

The technique provides sensitivity and selectivity to assay a wide variety of samples for non-volatile organic compounds including large biomolecules.  Tandem quadrupole LC-MS/MS  quantifies more pesticides and tests for more drugs-of-abuse than perhaps any other analytical technique. Mass spectrometry was commercialized by Finnigan in the late 1960s and some of the LC-MS/MS techniques were developed by Yost and Enke in 1978. Interfacing the LC to the MS provided the most challenges and went through a series of interactions from direct injection and moving belt interfaces to the techniques of atmospheric pressure chemical ionization and electrospray ionization.
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